Hirschsprung’s disease is a disease involving mainly the large intestine. It affects the nerve cells (Ganglion cells) in the large intestine and sometimes also the small intestine. These nerve cells control the muscles that move (Peristalsis) food and waste, or stool, through the large intestine and finally stools are excreted through the anus. During development, a baby’s nerve cells form along the intestines. They begin in the mouth and end in the anus.