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2017/07/31

United States

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2.

This antibody-cytokine fusion protein was achieved by conjugating/fusing the Anti-EpCAM IgG to IL2. It was expressed in CHO and purified with affinity chromatography. The immunocytokine retains the ability to bind the EpCAM as well as the biological activity of IL2. An Igγ4 version of the huKS-huγ1-huIL2 fusion protein was prepared by removing the immunoglobulin constant region Cγ1 gene fragment and replacing it with the corresponding sequence from the human Cγ4 gene. This immunocytokine was designed for treating solid tumor. http://www.creativebiolabs.net/Anti-EpCAM-Immunocytokine-IgG-huKS-IL2-22502.htm

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