Summary: https://www.creative-biolabs.com/adc/target-lypd3-66.htm This ADC product is comprised of an anti-LYPD3 monoclonal antibody (clone B01-3) conjugated via a lysine linker to toxophore. Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
Description: https://www.creative-biolabs.com/adc/target-lypd3-66.htm This ADC product is comprised of an anti-LYPD3 monoclonal antibody (clone B01-3) conjugated via a lysine linker to toxophore. Noncleavable linkers, is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
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