Summary: A significant portion of membrane proteins, especially transporters and receptors, are considered targets for drugs. By far, more than 60% of FDA-approved antibody therapies target membrane proteins, which has attracted an immense attention in the pharmaceutical industry. Despite of their essential roles in both industrial and academic researches, the isolation and characterizations of membrane proteins can be very challenging, not only due to their insolubility nature, but also because they often fold into conformationally complex structures that are difficult to retain outside of the cell.
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