Summary: "The vector of anti-FRα chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human FRα. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-FRα antibody linked to CD28 transmembrane domain/ endodomain and CD137 (4-1BB), CD3-zeta signaling domains. And the vector product was designed for the treatment of ovarian cancer. https://www.creative-biolabs.com/car-t/pcdcar1-fr%CE%B1-h-28bb%CE%B6-t-525.htm"
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