Summary: "The vector of anti-PD-1 chimeric antigen receptor (CAR) is constructed for the engineering of T cells to target human PD-1. The T cells are genetically modified through transduction with a lentiviral vector expressing scFv of anti-PD-1 antibody linked to a CD28 transmembrane domain/ endodomain and CD3-zeta signaling domains. And the vector product was designed for the treatment of B-cell malignancies. https://www.creative-biolabs.com/car-t/pcdcar1-pd-1-h-28%CE%B6-t-471.htm"
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