TypeName: Business Offer
Offer Date:2019/07/03
Country: United States
Summary: The AMP-activated protein kinase (AMPK) is a critical regulator of energy homeostasis, and is a potential target for treatment of metabolic diseases as well as cancer. Activation of AMPK requires phosphorylation of threonine 172 within the T loop region of the catalytic 汐2 subunit by the tumor suppressor LKB1 or the Ca 2+ /calmodulin-dependent protein kinase kinase beta (CaMKKβ). CaMKKβ can form a complex with and activate AMPK, but CaMKK汐 cannot. In addition, it was shown that CaMKKβ and AMPK associate through their kinase domains, and CaMKKβ must be in an active conformation in order to bind AMPK but not to associate with an alternative substrate, Ca 2+ /calmodulin-dependent protein kinase IV. In contrast to LKB1, the activation of AMPK by CaMKKβ does not require an alteration of the ATP:AMP ratio, but rather occurs in response to an increase in intracellular Ca 2+ . The expression pattern of CaMKKβ in cells and tissues is more limited than that of LKB1
Description: CAMKK2 Assay Kit is used for the measurement of the activities of purified or recombinant CAMKK22. Additionally, any cultured primary cell, cell line, or tissue can be assayed for CAMKK2 activity with the CAMKK2 Assay Kit if the appropriate dose of CAMKK2 specific inhibitor e.g. STO-609 is used.
http://www.creativebiomart.net/CAMKK2-Assay-Kit-462454.htm
OfferId: 4768
Name:Caroline Green
Telphone:
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