Summary: Ca2+/CaM-dependent protein kinase II (CaM kinase II) is a ubiquitously expressed protein kinase that transduces elevated Ca2+ signals in cells to a number of target proteins ranging from ion channels to transcriptional activators. CaM kinase II has a unique holoenzyme structure and autoregulatory properties that allow it to give a prolonged response to transient Ca2+ signals and to sense cellular Ca2+ oscillations. In neurons CaM kinase II is highly expressed and localized with certain subcellular structures. Upon activation it can translocate to excitatory synapses where it regulates a number of proteins involved in synaptic transmission and its downstream signaling pathways. Changes in intracellular calcium can display variable responses ranging from highly localized, transient elevations within subcellular structures (e.g. a dendritic spine of a neuron) to Ca2+ waves that spread throughout the cell including the nucleus. The most ubiquitous calcium-sensing protein is Calmodulin (CaM
Description: CaM-kinase II (Human) Assay Kit is a single-site, non-quantitative immunoassay for CaM kinase II activity. Plates are pre-coated with a newly designed Syntide-2, which can be efficiently phosphorylated by CaM kinase II on a microtiter plate. The detector antibody is MS-6E6, an antibody that specifically detects only the phosphorylated Syntide-2.
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