Summary: Creative Biolabs provides SmarterTM Self-destruct CAR construction service for customers across the world. CAR-T cells, re-directed to tumor-associated antigens (TAA), have shown promising results in clinical trials and some patients have even undergone complete tumor regression. However, current CAR-T cell therapy needs more careful balance between T-cell activation (ensure antitumor activity) and the potential of uncontrolled activation that may induce immunopathology.
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