Summary: Creative Biolabs provides SmarterTM Armored CAR construction service for customers across the world. Compared to CAR-T cells generated with traditional CARs, Armored CAR-T cells express immune checkpoint receptors that are able to regulate immune checkpoint signaling. High expression of immune checkpoint ligand is an efficient way for tumor cells to escape immune surveillance. This immune escape mechanism is also a major way for tumor cells to avoid adoptive T cell therapy. The tumor microenvironment contributes significantly to tumor development by inhibiting immune responses.
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