DNA Methyltransferase Activity/Inhibition Assay Kit (Colorimetric)
TypeName: Business Offer
Category:
Offer Date:2017/08/11
Country: United States
Summary: Epigenetic inactivation of genes plays a critical role in many important human diseases, especially in cancer. A core mechanism for epigenetic inactivation of the genes is methylation of CpG islands in genome DNA. Methylation of CpG islands involves the course in which DNA methyltransferases (Dnmts) transfer a methyl group from S-adenosyl-L-methionine to the fifth carbon position of the cytosines. Four active DNMTs have been identified in mammals-DNMT1, DNMT2, DNMT3A, and DNMT3B. The inhibition of DNMTs may lead todemethylation and expression of the silenced genes. DNMT inhibitors are currently being developed as potential anticancer agents.Currently, there are very narrow selections of methods to use for measuring DNMT activity or inhibition. These methods are time consuming, labor-intensive, have low throughput, or produce radioactive waste. The DNA Methyltransferase Activity/Inhibition Assay Kit (Colorimetric) by using a unique procedure to measure DNMT activity or inhibition.
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