Summary: Aurora-A is a key member of a closely related subgroup of serine/threonine kinases that belongs to the Drosophila aurora and Saccharomyces cerevisiae Ipl1 kinase family, and both are essential for chromosome segregation and centrosome functions. Aurora-A kinase has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumor types. It has been reported that amplification of Aurora-A in approximately 12% of primary breast tumors, as well as in breast, ovarian, colon, prostate, neuroblastoma, and cervical cancer cell lines. Additionally, high expression of Aurora-A mRNA was detected in tumor cell lines without evidence of gene amplification. Ectopic expression of Aurora-A in mouse NIH 3T3 cells led to the appearance of abnormal centrosome number (amplification) and transformation in vitro. Finally, overexpression of Aurora-A in near-diploid human breast epithelial cells revealed similar centrosome abnormality, as well as induction
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