TypeName: Business Offer
Offer Date:2018/09/29
Country: United States
Summary: JQ-1, a selective BET bromodomain inhibitor with antiproliferative activity, is highly active against human leukemia OCI-AML3 mutation lines such as nucleophosmin (NPM1) and DNA methyltransferase 3 (DNMT3A).Enantiomerically pure (+)-JQ1 binds to BRD4 bromodomains but the (−)-JQ1 stereoisomer has no palpable affinity to BET bromodomains.
IC 50/nM: BRD2 (N)= 17.7 ± 0.7, BRD4 (N)= 76.9 ± 1.7, BRD4 (C)= 32.6 ± 1.8;
K d/nM: BRD2 (N)= 128±6.5, BRD3 (N)= 59.5 ± 3.1, BRD3 (C)= 82.0 ±5.3, BRD4 (N)= 49.0 ± 2.4, BRD4 (C)= 90.1 ± 4.6.
https://www.bocsci.com/jq-1-cas-1268524-70-4-item-453787.html
Description: [RequestDescription]
OfferId: 2158
Name:Alex Brown
Telphone:
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