Summary: The carbohydrate moiety on an antibody is located at the hinge region of the Fc domain, with a sufficient distant from the variable region that regulates antigen interaction. Therefore, conjugation involving carbohydrate moiety is unlikely to impair the antigen binding affinity and could potentially serves as an excellent alternative for site-specific antibody drug conjugate (ADC) generation. With years of experience in antibody engineering and ADC development, Creative Biolabs now offers clients three elaborate strategies to target carbohydrate moiety for the conjugation of payload drugs: (1) glycan chemical oxidation, (2) glycan enzymatic and chemo-enzymatic modification, and (3) carbohydrate moiety metabolic engineering. Using our well-established carbohydrate-based conjugation methods, Creative Biolabs is dedicated to develop customized ADCs to fit your requirements, timeline, and R&D budget. Creative Biolabs offers ADC development services using payload conjugation to the modified
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