Summary: Taking advantage of the intein-fusion technology, Creative Biolabs provides our clients with high-quality antibody-drug conjugates (ADCs) in a time efficient manner. Intein-fusion technology is developed based on inteins, a class of peptides that undergo self-cleavage when inserted into precursor proteins. Intein-fusion has been widely used to produce recombinant proteins with site-specific incorporation of a diverse set of chemical modifications. Recently, this technology has been used as an innovative solution for specific C-terminal modification of antibodies and further facilitates the site-directed conjugation with various cytotoxic drugs to generate homogeneous ADC products. At Creative Biolabs, we have established two different strategies for intein-fusion, namely expressed protein ligation (EPL) and protein trans-splicing (PTS). We are committed to offering top-quality conjugation service using these techniques to meet your ADC development requirements. Creative Biolabs provide
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