Summary: SSAO"s functional role has been suggested to be involved in: apoptosis, atherogenesis, cell adhesion, leucocyte trafficking, glucose transport and local production of hydrogen peroxide. Elevated levels of SSAO have been reported in congestive heart failure, diabetes mellitus, alzheimer"s disease and various other inflammatory diseases. In addition, by products of SSAO deamination, such as formal-dehyde and methylglyoxal, have been proposed to be involved in pathogenesis of cancer, aging and atherosclerosis. The Fluoro SSAO detection kit utilizes a non-fluorescent detection reagent to measure H2O2 released from the conversion of Benzylamine to Benzaldehyde via SSAO. Furthermore, H2O2 oxidizes the detection reagent in a 1:1 stoichiometry to produce a fluorescent product resorufin. This oxidation is catalyzed by Peroxidase.
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