Anti-TNFRSF8 (CA10)-β-glucuronide-CBI Minor Groove Binder ADC
TypeName: Business Offer
Category:
Country: United States
Summary: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (CA10) conjugated via a β-glucuronide linker to a CBI Minor Groove Binder. β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
Description: This ADC product is comprised of an anti-TNFRSF8 monoclonal antibody (CA10) conjugated via a β-glucuronide linker to a CBI Minor Groove Binder. β-Glucuronide linkers belong to Enzymatically cleavable linkers, which have expected stability and provide facile release of the active drug. The cleavage of the β-glucuronide glycosidic bond relies on lysosomal enzyme β-glucuronidase, and this enzyme is abundantly present within lysosomes and is overexpressed in some tumor types, while the enzyme activity outside cells is low.
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