Advanced wound therapy includes innovative techniques for healing complex wounds, notably skin substitute grafting and negative pressure wound therapy (NPWT). Skin Substitute Grafting uses biological or synthetic materials to support damaged skin, mimicking its properties to create a protective barrier and encourage new tissue growth. This method improves moisture retention and reduces infection, leading to better outcomes for chronic or non-healing wounds. Negative Pressure Wound Therapy (NPWT) employs a specialized device that applies sub-atmospheric pressure to the wound bed, enhancing blood flow, reducing edema, and assisting fluid drainage. The negative pressure fosters granulation tissue formation, speeds up wound contraction, and potentially shortens healing times, especially for difficult wounds like diabetic ulcers and surgical injuries.